Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 911-553-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16.-19.11.18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Test temperature:
- 25 ± 0.5 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC Ultimate3000
- Type:
- Type, material and dimension of analytical (guard) column: Dr. Maisch Reprosil Pur 120 CN (125x4.6 mm, S/N 50318, 2902 02) with precolumn Phenomenex Security Guard CN, 4x3 mm
- Detection system: UV Detector MWD-3000 (220 nm)
MOBILE PHASES
- Type: MeOH/H2O 55/45 (% v/v)
- Experiments with additives carried out on separate columns: yes / no
- pH: 5-6
- Solutes for dissolving test and reference substances:
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (Sodium Nitrate, NaNO3, CAS 7631-99-4)
REFERENCE SUBSTANCES
- Identity: Acetanilide (CAS 103-84-4), Methylbenzoate (CAS 93-58-3), Naphthalene (CAS 91-20-3), 1,2,3-trichlorobenzene (CAS 87-61-1), Phenanthrene (CAS 85-01-8), DDT (CAS 50-29-3)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µg
- Quantity of reference substances:
- Intervals of calibration:
REPETITIONS
- Number of determinations: 6 (reference substances), 3 (test substance)
EVALUATION
- Calculation of capacity factors k':
- Calculation of retention times:
- Determination of the log K-oc value: log k’ = 0.2395 * logKOC – 0.1083 - Key result
- Type:
- log Koc
- Value:
- > 5.63
- pH:
- 5
- Temp.:
- 25 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Acetanilide 2.700, Methylbenzoate 3.149, Naphthalene 4.476, 1,2,3-trichlorobenzene 5.283, Phenanthrene 7.583, DDT 20.574
- Details of fitted regression line (log k' vs. log Koc): log k’ = 0.2395 * logKOC – 0.1083 with a coefficient of determination r2 = 0.9900
- Average retention data for test substance: 33.001 - Validity criteria fulfilled:
- yes
- Conclusions:
- As the substance is not eluted within the isocratic part of the HPLC program, the log KOC of the test item is stated as > 5.63 (log KOC of DDT, reference item mix com-ponent with the highest log KOC).
- Executive summary:
The study was performed using a HPLC with a cyanopropyl chemical bound resin on a silica base column. Six reference items with different retention times were used to produce a calibration curve, since retention time on cyanopropyl columns and KOC are correlated. The reference items were chosen on behalf of the retention time of the test item N-(hydroxymethyl) stearamide based on the results of the pre-test.
A solvent blank followed by three injections of a solution of the reference items were analysed with HPLC, then three injections of a solution of the test item; and finally three injections of the solution with the reference items, in total ten runs.
For each reference item, the capacity factor k’ was calculated from the retention time of sodium nitrate and the retention time of the respective reference item. A calibration function was set up using the literature values for KOC of the reference items and the mean capacity factor of the six determinations. In the graph log k’ versus log KOC, linear regression was performed, giving r2 = 0.9900.
The chromatogram of the test item gave one peak (mean RT = 33.001 min). The test item did not elute within the isocratic part of the method, therefore calculation of the log KOC of the test item N-(hydroxymethyl) was not possible.
The log KOC of the test item is stated as > 5.63 (reference item with the highest log KOC DDT with a log KOC of 5.63.
Reference
Description of key information
The key value is determined in a HPLC screening study. As the substance is not eluted within the isocratic range of the determination, the value is estimated to be > 5.63. For the assessment this value is used.
Key value for chemical safety assessment
- Koc at 20 °C:
- 426 580
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
