Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: Expert review and assessment
Adequacy of study:
key study
Study period:
Report Issued: 26 November 2018.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Not assignable as the result is from an expert assessment.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Expert review of available data at REACH Annex VIII tonnage band.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bromoform
EC Number:
200-854-6
EC Name:
Bromoform
Cas Number:
75-25-2
Molecular formula:
CHBr3
IUPAC Name:
bromoform

Results and discussion

Applicant's summary and conclusion

Conclusions:
Observations from an acute oral study and repeated dose oral toxicity studies demonstrate that Bromoform can be rapidly absorbed from the gastrointestinal system. It is also anticipated that an inhaled dose will be rapidly absorbed across lung membranes.

Systemically absorbed Bromoform can be expected to be excreted rapidly via exhalation either as parent compound, or as CO2 derived from metabolic breakdown.
Executive summary:

Introduction

An expert review of toxicokinetic data on Bromoformv was undertaken to provide a basic toxicokinetic asessment as required for REACH Annex VIII registration. The assessment was based on available data from toxicological studies studies and some literature references. No specific toxicokinetic studies were undertaken.

Conclusion

Observations from an acute oral study and repeated dose oral toxicity studies demonstrate that Bromoform can be rapidly absorbed from the gastrointestinal system.  It is also anticipated that an inhaled dose will be rapidly absorbed across lung membranes.  

Systemically absorbed Bromoform can be expected to be excreted rapidly via exhalation either as parent compound, or as CO2 derived from metabolic breakdown.