Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
2.7
Temp.:
20 °C
pH:
7
Remarks on result:
other: Log Kow representative of peak 8 (highest peak area at 30%)
Type:
log Pow
Partition coefficient:
1.42
Temp.:
20 °C
pH:
7
Remarks on result:
other: Weighted average Log Kow value (including peaks contributing a peak area of 5% or more) as the substance constituents are considered homologous.
Details on results:
18 constituent peaks were identified of which the Log Kow values could be determined for 14 (within the range of reference substances). Log Kow values ranged from < 1.1 to 5 (reference range 1.1 to 7.2).

Any other information on results incl. tables

Log Pow of the test item:

Substance

Retention time (min)

log Pow

Pow

Peak area
(%)

tr,1

tr,2

mean

Formamide (t0)

0.787

0.827

0.807

 

 

 

Benzylalcohol

1.070

0.984

 

1.1

 

 

Nitrobenzene

1.327

1.220

 

1.9

 

 

Toluene

2.147

1.974

 

2.7

 

 

1,4-Dichlorobenzene

2.783

2.562

 

3.4

 

 

Biphenyl

3.760

3.464

 

4.0

 

 

Dibenzyl

6.293

5.806

 

4.8

 

 

Triphenylamine

11.575

10.689

 

5.7

 

 

4,4’-DDT

16.557

15.320

 

6.5

 

 

Benzo[ghi]perylene

22.159

22.293

 

7.2

 

 

Test item – peak 1

0.528

0.529

0.529

n.a.*

n.a.*

3.5

Test item – peak 2

0.608

0.606

0.607

n.a.*

n.a.*

17

Test item – peak 3

0.666

0.666

0.666

n.a.*

n.a.*

2.1

Test item – peak 4

0.711

0.715

0.713

n.a.*

n.a.*

5.1

Test item – peak 5

0.888

0.895

0.892

< 1.1#

< 1.3 x 101 #

5.6

Test item – peak 6

1.344

1.346

1.345

1.9

8.4 x 101

3.5

Test item – peak 7

1.438

1.437

1.438

2.1

1.4 x 102

0.62

Test item – peak 8

1.776

1.774

1.775

2.7

5.2 x 102

30

Test item – peak 9

1.889

1.888

1.889

2.9

7.3 x 102

1.6

Test item – peak 10

1.984

1.993

1.989

3.0

9.5 x 102

0.37

Test item – peak 11

2.172

2.164

2.168

3.2

1.5 x 103

0.79

Test item – peak 12

2.435

2.435

2.435

3.4

2.6 x 103

2.1

Test item – peak 13

2.741

2.741

2.741

3.6

4.3 x 103

4.5

Test item – peak 14

2.827

2.828

2.828

3.7

5.0 x 103

4.3

Test item – peak 15

3.400

3.473

3.437

4.0

1.1 x 104

2.6

Test item – peak 16

3.598

3.592

3.595

4.1

1.3 x 104

6.4

Test item – peak 17

4.266

4.260

4.263

4.4

2.6 x 104

4.0

Test item – peak 18

6.023

6.053

6.038

5.0

9.3 x 104

5.8

* The Log Kow and Kow values of these peaks could not be calculated because tr < tr of formamide (the lowest reference substance).

# tr < tr of benzylalcohol therefore Log Kow and Kow values of this peak are reported as < 1.1 and < 13

Applicant's summary and conclusion

Conclusions:
The substance is a UVCB and as such ranges of Log Kow values were provided. The weighted average of the Log Kow values of the various peaks representing at least 5% of the peak area was determined to be 1.42 at 20°C. When considering the peak with the largest peak area (30%), this provides a Log Kow value of 2.7.