Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-815-8 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Reaction product aqueous Phosphoric Acid, 1-Methoxypropan-2-ol and 4,4'-Isopropylidenediphenol-Epichlorohydrin
- EC Number:
- 944-815-8
- Molecular formula:
- Not possible to assign for a complex UVCB substance
- IUPAC Name:
- Reaction product aqueous Phosphoric Acid, 1-Methoxypropan-2-ol and 4,4'-Isopropylidenediphenol-Epichlorohydrin
- Test material form:
- liquid
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- 2.7
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: Log Kow representative of peak 8 (highest peak area at 30%)
- Type:
- log Pow
- Partition coefficient:
- 1.42
- Temp.:
- 20 °C
- pH:
- 7
- Remarks on result:
- other: Weighted average Log Kow value (including peaks contributing a peak area of 5% or more) as the substance constituents are considered homologous.
- Details on results:
- 18 constituent peaks were identified of which the Log Kow values could be determined for 14 (within the range of reference substances). Log Kow values ranged from < 1.1 to 5 (reference range 1.1 to 7.2).
Any other information on results incl. tables
Log Pow of the test item:
Substance |
Retention time (min) |
log Pow |
Pow |
Peak area |
||
tr,1 |
tr,2 |
mean |
||||
Formamide (t0) |
0.787 |
0.827 |
0.807 |
|
|
|
Benzylalcohol |
1.070 |
0.984 |
|
1.1 |
|
|
Nitrobenzene |
1.327 |
1.220 |
|
1.9 |
|
|
Toluene |
2.147 |
1.974 |
|
2.7 |
|
|
1,4-Dichlorobenzene |
2.783 |
2.562 |
|
3.4 |
|
|
Biphenyl |
3.760 |
3.464 |
|
4.0 |
|
|
Dibenzyl |
6.293 |
5.806 |
|
4.8 |
|
|
Triphenylamine |
11.575 |
10.689 |
|
5.7 |
|
|
4,4’-DDT |
16.557 |
15.320 |
|
6.5 |
|
|
Benzo[ghi]perylene |
22.159 |
22.293 |
|
7.2 |
|
|
Test item – peak 1 |
0.528 |
0.529 |
0.529 |
n.a.* |
n.a.* |
3.5 |
Test item – peak 2 |
0.608 |
0.606 |
0.607 |
n.a.* |
n.a.* |
17 |
Test item – peak 3 |
0.666 |
0.666 |
0.666 |
n.a.* |
n.a.* |
2.1 |
Test item – peak 4 |
0.711 |
0.715 |
0.713 |
n.a.* |
n.a.* |
5.1 |
Test item – peak 5 |
0.888 |
0.895 |
0.892 |
< 1.1# |
< 1.3 x 101 # |
5.6 |
Test item – peak 6 |
1.344 |
1.346 |
1.345 |
1.9 |
8.4 x 101 |
3.5 |
Test item – peak 7 |
1.438 |
1.437 |
1.438 |
2.1 |
1.4 x 102 |
0.62 |
Test item – peak 8 |
1.776 |
1.774 |
1.775 |
2.7 |
5.2 x 102 |
30 |
Test item – peak 9 |
1.889 |
1.888 |
1.889 |
2.9 |
7.3 x 102 |
1.6 |
Test item – peak 10 |
1.984 |
1.993 |
1.989 |
3.0 |
9.5 x 102 |
0.37 |
Test item – peak 11 |
2.172 |
2.164 |
2.168 |
3.2 |
1.5 x 103 |
0.79 |
Test item – peak 12 |
2.435 |
2.435 |
2.435 |
3.4 |
2.6 x 103 |
2.1 |
Test item – peak 13 |
2.741 |
2.741 |
2.741 |
3.6 |
4.3 x 103 |
4.5 |
Test item – peak 14 |
2.827 |
2.828 |
2.828 |
3.7 |
5.0 x 103 |
4.3 |
Test item – peak 15 |
3.400 |
3.473 |
3.437 |
4.0 |
1.1 x 104 |
2.6 |
Test item – peak 16 |
3.598 |
3.592 |
3.595 |
4.1 |
1.3 x 104 |
6.4 |
Test item – peak 17 |
4.266 |
4.260 |
4.263 |
4.4 |
2.6 x 104 |
4.0 |
Test item – peak 18 |
6.023 |
6.053 |
6.038 |
5.0 |
9.3 x 104 |
5.8 |
* The Log Kow and Kow values of these peaks could not be calculated because tr < tr of formamide (the lowest reference substance).
# tr < tr of benzylalcohol therefore Log Kow and Kow values of this peak are reported as < 1.1 and < 13
Applicant's summary and conclusion
- Conclusions:
- The substance is a UVCB and as such ranges of Log Kow values were provided. The weighted average of the Log Kow values of the various peaks representing at least 5% of the peak area was determined to be 1.42 at 20°C. When considering the peak with the largest peak area (30%), this provides a Log Kow value of 2.7.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
