Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-281-9 | CAS number: -
Table: Body weights and body weight gain.
Individual data, mean and standard deviation SD.
Body weight (g)
Body weight gain (g)
Table: Observations in life.
Dose(mg / kg), sex
No. of the affected animals
Observation time(p.a.) first last
4 h - 6 h
test substance related stain of skin
1 d - 14 d
1 d - 12 d
1 d - 13 d
Table: Necropsy findings.
Dose(mg / kg)sex
No. of affectedanimals
no abnormal findings
11, 12, 13, 14, 15
16, 17, 18, 19, 20
The aim of the study was to investigate acute toxic effects of the test substance after a single dermal administration to rats.
Methods and investigations were performed in conformance with the OECD-Guideline 402, 1987 and theCouncil Regulation (EC) No 440/2008, Method B.3.
Administration of the test substance
"3-hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde"was administered once topically on an area of approximately 6.5 cm x 8 cm on the dorsal thoracicregion of 5 male and 5 female Sprague Dawley rats.
The dose was 2000 mg per kg body weight.
A cellulose patch with the calculated amount of the test substance on the surface and soaked with deionised water to get optimal contact with the skin, was applied to the test site and held in place by fixing marginally with non irritating tape.
The test site was covered by a semi-occlusive dressing.
The duration of the exposure was 24 hours.
· Body weights: before the administration, 7 and 14 days after the administration (p.a.).
· Clinical observations: at least once per day.
· Necropsy: All animals were sacrificed and necropsied 14 days p.a.
No. of animals
Staining of the skin which is attributed to the staining property of the test substance was observed in all animals.
presence of clinical signs in 1/10 animals
from 4 h to 6 h p.a.
full recovery of the animal
all animals gained weight in both weeks p.a.
findings in life and post-mortem indicate
no toxic effects present
> 2000 mg/kg body weight
No local or systemic toxic effects related to administration of the test substance were noted from clinical observations or post-mortem-examination at a dose of 2000 mg of the test substance per kg body weight.
No mortality occurred.
No classification of"3-hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde"is therefore derived from the results of this study according to the Directive 2001/59/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again