Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-281-9 | CAS number: -
Table: Body weights and body weight gain
Individual data, means and standard deviations SD.
Body weight (g)
Body weight gain (g)
mg/kg (Step No.)
Table: Observations in life
A grade of severity was recorded where applicable (low - mid - high).
Dose(mg/kg), Step No.
Observation time(p.a.)first last
signs of reduced well-being
21, 22, 23
1 h / 6 h
24, 25, 26
Table: Necropsy findings
Number of animals examined: 6 females.
no abnormal findings
The aim of the study was to investigate acute toxic effects of the test substance after a single peroral administration to rats.
Methods and investigations were performed in conformance with the OECD-Guideline 423, 17 December 2001 and theCouncil Regulation (EC) No 440/2008,Method B.1 tris.
Administration of the test substance
"3-hydroxy-2-(hydroxymethyl)-2-methylpropionaldehyde"was administered once orally via gavage as a solution in deionised water to female Crl:CD(SD) rats.
The dosing was performed sequentially to groups of 3 animals per step using a starting dose 2000 mg per kg body weight.
The dose volume was 10 mL per kg body weight for all groups.
· Body weights: before administration, 7 and 14 days after the administration (p.a.).
· Clinical observations: at least once per day.
· Necropsy: The animals were sacrificed and necropsied 14 days p.a.
No. of animals
Presence of signs in life
from 1 h until 6 h p.a.
Full recovery of the animals
all animals gained weight in both weeks p.a.
Findings in life and post mortem indicate
no severe toxic effects present
LD50, oralaccording to OECD
> 5000 mg/kg body weight
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again