(R)-3,7-dimethyl-1,6-octadien-3-ol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(R)-3,7-dimethyl-1,6-octadien-3-ol

EC Number:

204-811-2

EC Name:

(R)-3,7-dimethyl-1,6-octadien-3-ol

Cas Number:

126-91-0

Molecular formula:

C10H18O

IUPAC Name:

(3R)-3,7-dimethylocta-1,6-dien-3-ol

Test material form:

liquid

Test solutions

Vehicle:

not specified

Details on test solutions:

The primary stock solution used in the range-finding test was prepared by dissolving 10 mg of the test substance in 40 mL of dilution water – M4 and the total volume was completed to 100 mL, resulting in a concentration of 100 mg.L-1. The secondary stock solutions of the 10; 1 and 0,1 mg.L-1 were prepared by dilutions of the primary stock solution.
The primary stock solution used in the definitive test was prepared by dissolving 50 mg of the test substance in 40 mL of dilution water – M4 and the total volume was completed to 500 mL, resulting in a concentration of 100 mg.L-1.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Crustacea
Class: Branchiopoda
Order: Cladocera
Family: Daphniidae
Genus: Daphnia
Species: Daphnia magna
Young Daphnia magna ≤ 24 hours old were obtained from the culture kept at the Ecotoxicology Laboratory, maintenance and cultivation records are archived at BIOAGRI.

Study design

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

48 h

Test conditions

Hardness:

196.7 mg.L-1 CaCO3

Test temperature:

20.1 to 20.2°C

pH:

7.7

Dissolved oxygen:

8.0 mg.L-1

Conductivity:

459

Reference substance (positive control):

yes

Results and discussion

Effect concentrations

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 51.86 mg/L

Conc. based on:

test mat.

Remarks on result:

other: (95% confidence limits = 43.61 to 61.68 mg.L-1).

Results with reference substance (positive control):

The 24-hours EC50 value of the reference substance (potassium dichromate) was 1.05 mg.L-1 (95% confidence limits = 0.91 to 1.21 mg.L-1), showing the sensitivity of the test system (ISO 6341 / OECD 202, 2004).

Applicant's summary and conclusion

Conclusions:

The 48-hours EC50 value of (R)-3,7-dimethyl-1,6-octadien-3-ol was 51.86 mg.L-1 (95% confidence limits = 43.61 to 61.68 mg.L-1).