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EC number: 948-383-1 | CAS number: -
Table 1: Preparation of test solutions
Test substance [µL] or reference substance [mL]
Synthetic sewage [mL]
RO water [mL]
Microbial Inoculum [mL]
Test substance [mg/L]
Reference substance [mg/L]
Table 2: Dissolved oxygen concentration and measurement times
Initial dissolved oxygen conc. in culture [mg O2/L]
Initial measured dissolved oxygen conc. [mg O2/L]
Final measured dissolved oxygen conc. [mg O2/L]
Measurement time [min]
Table 3: Measurement of respiration rate
Specific respiration rate [mg O2/g/h]
% inhibition or stimulation ()
Since no studies investigating the toxicity of Fatty acids, C8-10-(even numbered), esters with pentaerythritol and adipic acid (EC 948-383-1) to microorganisms are available, in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5, a read-across to the structurally related source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted. The source substance is representative to evaluate the toxicity of the target substance to microorganisms. This read-across is justified in detail within the analogue justification in IUCLID section 13.
The study with the source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted under GLP in a static test design according OECD Guideline 209 (Respiration Inhibition Test), using activated sludge from predominantly domestic sewage. Three nominal concentrations of 10, 100 and 1000 mg/L of the test substance were prepared. The respiration rate was measured after a test period of 3 h. The test substance showed no inhibitory effect on the respiration rate of activated sludge at any of the concentrations employed in the test. Therefore, effect values of EC50 (3 h) > 1000 mg/L (nominal) and EC10 (3 h) > 1000 mg/L (nominal) were determined.
Based on this result obtained from the source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) (in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that the target substance Fatty acids, C8-10-(even numbered), esters with pentaerythritol and adipic acid (EC 948-383-1) is non-inhibitory of aquatic microorganisms activity and further testing for this endpoint is regarded not necessary.
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