Antimony, mixed dipentyldithiocarbamate and bis(2-ethylhexyl)dithiocarbamate complexes

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

February 6, 1961

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1961

Report date:

1961

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Conducted before implementation of OECD Guidelines for Testing of Chemicals and GLP. Species, number and sex of animals, body weight measurement, dose preparation, and treatment conditions are described. Test substance characterization and batch number are not included in the study report.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

1

Reference substance name:

Reaction mass of tris(dipentyldithiocarbamato-S,S')antimony and [bis(2-ethylhexyl)dithiocarbamato-S,S']bis(dipentyldithiocarbamato-S,S')antimony and bis[bis(2-ethylhexyl)dithiocarbamato-S,S'](dipentyldithiocarbamato-S,S')antimony and tris[bis(2-ethylhexyl)dithiocarbamato-S,S']antimony

IUPAC Name:

Reaction mass of tris(dipentyldithiocarbamato-S,S')antimony and [bis(2-ethylhexyl)dithiocarbamato-S,S']bis(dipentyldithiocarbamato-S,S')antimony and bis[bis(2-ethylhexyl)dithiocarbamato-S,S'](dipentyldithiocarbamato-S,S')antimony and tris[bis(2-ethylhexyl)dithiocarbamato-S,S']antimony

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

not specified

Remarks:

Albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 160 to 290 g
- Fasting period before study: 18 ± 2 hours
- Housing: Individual cages
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

cotton seed oil

Details on oral exposure:

- Test substance: Dosed as 10 - 40% in cottonseed oil
- Vehicle: Cottonseed oil
-Test conditions: Orally dosed as 10 - 40% in cottonseed oil at 1.0, 2.1, 4.1, 8.2, 11.6, or 16.4 g/kg bw as a single dose

No. of animals per sex per dose:

3/sex/dose

Details on study design:

Morbidity, mortality, and clinical signs were recorded for 14 days. Body weights were recorded on days 0 and 14. Gross necropsies were performed.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 16.4 other: g/kg bw

Based on:

test mat.

Mortality:

All animals survived the 14 day post-dose observation period.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Under the conditions of the study, the LD50 for acute oral toxicity of the test item has been determined as greater than 16.4 g/kg bw.

Executive summary:

An acute oral toxicity study was performed on the Read-Across substance Antimony Dipentyldithiocarbamate. Although no guidelines were stated within the study, the methodology is similar or equivalent to the standardized OECD 401; hence the study has been assigned a Klimisch score of 2.

The study was conducted before implementation of OECD Guidelines for Testing of Chemicals and GLP. However, the species, number and sex of animals, body weight measurement, dose preparation, and treatment conditions are described; yet, test item characterization and batch number are not included in the study report.

Albino rats, (3 per sex per group, for 6 groups) were orally dosed as 10 to 40 percent in cottonseed oil at 1.0, 2.1, 4.1, 8.2, 11.6, or 16.4 g/kg bw as a single dose.

Morbidity, mortality, and clinical signs were recorded for 14 days. Body weights were recorded on days 0 and 14. Gross necropsies were performed. All animals survived the 14 day post-dose observation period. The oral LD50 for both sexes was greater than 16.4 g/kg bw.