Registration Dossier
Registration Dossier
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EC number: 201-132-3 | CAS number: 78-67-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Title:
- No information
- Author:
- Takenaka, S.-I. et al.: J. Toxicol. Sci. 18, 418 (1993);|abstract no. P-225
Materials and methods
- Principles of method if other than guideline:
- Acredine orange staining
- GLP compliance:
- not specified
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- EC Number:
- 201-132-3
- EC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Cas Number:
- 78-67-1
- Molecular formula:
- C8H12N4
- IUPAC Name:
- 2,2'-dimethyl-2,2'-azodipropiononitrile
- Details on test material:
- IUCLID4 Test substance: no data
TS-Freetext:
2,2'-azobisisobutyronitrile; no data on purity of the
compound
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- double oral administration
Doses / concentrations
- Remarks:
- no data
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
Any other information on results incl. tables
negative
The mice were given a double oral dose of the test substance. At both 24
and 48 h after treatment, bone marrow
smears were prepared. Administration of the test substance did not
result in a significant increase in the frequency of micronucleated
polychromatic erythrocytes.
Only abstract available; no further data.
Applicant's summary and conclusion
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