Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Title:
No information
Author:
Takenaka, S.-I. et al.: J. Toxicol. Sci. 18, 418 (1993);|abstract no. P-225

Materials and methods

Principles of method if other than guideline:
Acredine orange staining
GLP compliance:
not specified
Type of assay:
micronucleus assay

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: no data

TS-Freetext:
2,2'-azobisisobutyronitrile; no data on purity of the
compound

Test animals

Species:
mouse
Strain:
other: ddY
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
double oral administration
Doses / concentrations
Remarks:
no data

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative

Any other information on results incl. tables

negative

The mice were given a double oral dose of the test substance. At both 24 and 48 h after treatment, bone marrow
smears were prepared. Administration of the test substance did not result in a significant increase in the frequency of micronucleated polychromatic erythrocytes.

Only abstract available; no further data.

Applicant's summary and conclusion