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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2018-06-20 to 2019-02-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
580 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
completely miscible
Details on results:
The water solubility at 20 °C of the test item was determined to be 580 mg/L (RSD = 0.3 %).

 Table 1: Preliminary test for the water solubility

Amount of test item [mg]

Total volume of added water [mL]

Stirring time [min]

Remark

106.08

0.1

--

not dissolved

0.6

1*

not dissolved

1.6

2*

not dissolved

3.6

2*

not dissolved

13.6

6*

not dissolved

100

6*

not dissolved

9.44

100

5625

dissolved

4.60

250

5625

dissolved

4.97

500

5625

dissolved

*Treatment in the ultrasonic bath.

 

The solubility of the test item in water at room temperature was estimated to be > 0.1 g/L and < 1.1 g/L. Therefore, the flask method was performed.

 

Table 2: Results of the flask method

Flask

1a

2a

3a

4a

measured value [g/L]

0.571 / 0.576

0.576/0.578

0.576/0,577

0 /0

average water solubility [g/L]

0.574

0.577

0.577

0

mean value of the water solubility [g/L]

0.58

0

standard deviation [g/L]

<0.01

--

relative standard deviation [%]

0.3

--

 

Conclusions:
The water solubility at 20 °C of the test item was determined to be 580 mg/L (RSD = 0.3 %)
Executive summary:

A study was performed in accordance with OECD 105 (1995) in order to determine the water solubility of the test item. The preliminary test at room temperature showed, that the water solubility of the test item was between 0.1 g/L and 1.1 g/L. For the main test three flasks were prepared with an amount of test item and water, and one flask only with water. After stirring and centrifugation the aqueous phases were measured by means of HPLC. The solution of each flask has been measured twice. To verify the accuracy of the analytical method two freshly prepared standard solutions (prepared with the test item) were measured in between the samples of the flask method. The recovery rate of the measured standard solutions was in the range from 99.5 % to 101.4 %, which shows a good accuracy of the analytical method. In conclusion, the water solubility at 20 °C of the test item was determined to be 580 mg/L (RSD = 0.3 %).

Description of key information

The water solubility at 20 °C of the test item was determined to be 580 mg/L.

Key value for chemical safety assessment

Water solubility:
580 mg/L
at the temperature of:
25 °C

Additional information

In order to determine the water solubility of the test substance a study was performed. According to OECD 105 (1995) and Regulation EC No 440/2008 Method A.6. the water solubility at 20 °C of the test item was determined to be 580 mg/L.