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EC number: 211-915-1 | CAS number: 710-04-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 20 March 2018 to 24 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 20 March 2018 to 24 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Key result
- Boiling pt.:
- 306.2 °C
- Atm. press.:
- >= 1 013 - <= 1 015 hPa
- Remarks on result:
- other: mean of 2 measurements
- Conclusions:
- The boiling temperature of the substance was determined to be 306.2°C (at 1014 ± 1 hPa).
- Executive summary:
The boiling temperature of the substance was determined using Differential Scanning Calorimetry in a GLP study according to EC A.2, OECD 103 and OPPTS 830.7220.
From duplicate experiments, the boiling temperature was determined to be 306.2°C (at 1014 ± 1 hPa).
Three DSC experiments were performed to investigate the melting and boiling behaviour of the substance.
DSC EXPERIMENT 1
During cooling, an exothermic peak between -30°C and -40°C was found (due to crystallization of the test item). During heating, two endothermic peaks and an exothermic peak were observed between -25°C and 25°C followed by an endothermic peak between 275°C and 325°C. The effects between -40°C and 25°C were ascribed to melting, re-crystallisation and melting of the substance (see endpoint 4.2). A third endothermic effect with an extrapolated onset temperature of 306.240°C was observed, probably caused by boiling of the test item. After the experiment it was observed that the test item had evaporated from the sample container.
DSC EXPERIMENT 2
In order to investigate the endothermic peak between 275°C and 325°C, a higher heating rate of 50°C/minute was used in Experiment 2. The extrapolated onset temperature of the observed endothermic effect was 306.549°C. Since the endothermic peak had not shifted to higher temperature, this test demonstrated that boiling of the test item caused the endothermic effect. After the experiment it was observed that the test item had evaporated from the sample container. Since a higher heating rate was used, the extrapolated onset temperature was not used in the calculation of the boiling point.
DSC EXPERIMENT 3
Experiment 3 was performed as a duplicate of Experiment 1. Similar results as in Experiment 1 were obtained. The extrapolated onset temperature of the boiling peak was 306.206°C.
DATA HANDLING
The boiling temperature was determined as the mean extrapolated onset temperature of the third endothermic effect measured in Experiment 1 (306.240°C) and Experiment 3 (306.206°C).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 6-hexyltetrahydro-2H-pyran-2-one
- EC Number:
- 211-915-1
- EC Name:
- 6-hexyltetrahydro-2H-pyran-2-one
- Cas Number:
- 710-04-3
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 6-hexyltetrahydro-2H-pyran-2-one
- Test material form:
- liquid
- Details on test material:
- Appearance: Clear colourless to pale yellow liquid
Test item storage: In refrigerator (2-8°C)
Constituent 1
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 1.7 °C
- Atm. press.:
- >= 1 013 - <= 1 015 hPa
- Remarks on result:
- other: mean of 2 measurements
Any other information on results incl. tables
Four experiments were performed to investigate the melting and boiling behaviour of the substance.
DSC EXPERIMENT 1
During cooling, an exothermic peak between -30°C and -40°C was found (due to crystallization of the test item). During heating, two endothermic peaks and an exothermic peak were observed between -25°C and 25°C followed by an endothermic peak between 275°C and 325°C. The effects between -25°C and 25°C were most likely obtained due to melting, followed by re-crystallisation and melting of the test item. The peak maximum of the second endothermic peak was 1.596°C. A third endothermic effect observed between 275°C and 310°C and ascribed to boiling (see endpoint 4.3).
DSC EXPERIMENT 2
Investigation of the presumed boiling peak, see endpoint 4.3.
DSC EXPERIMENT 3
Experiment 3 was performed as a duplicate of Experiment 1. Similar results as in Experiment 1 were obtained. The peak maximum of the second melting peak was 1.732°C.
STORAGE EXPERIMENT IN FREEZER
Two subsamples of the test item were placed overnight in a ≤ ‑15°C freezer and a ≤ -75°C freezer. It was observed after overnight storage that the test item was a liquid (≤ ‑15°C freezer; actual temperature -18.7 ± 0.3°C) and a solid (≤ -75°C freezer; actual temperature -83.3 ± 1.7°C). The subsample that had been stored in the ≤ -75°C freezer was transferred into the ≤ -15°C freezer. After three days of storage at an actual temperature of -18.8 ± 0.2°C, the test item was still a solid. Based on this, the second endothermic peak observed in Experiment 1 and Experiment 3 was reported as the melting point.
DATA HANDLING
The mean of the second melting peak of Experiment 1 (peak maximum temperature: 1.596°C) and Experiment 3 (peak maximum temperature: 1.732°C) was reported as the melting temperature.
Applicant's summary and conclusion
- Conclusions:
- The melting temperature of the substance was determined to be 1.7°C.
- Executive summary:
Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.
During heating, an endothermic peak, an exothermic peak and again an endothermic peak were observed between -25°C and 25°C. These effects were most likely obtained due to melting, followed by re-crystallisation and melting of the test item. The peak maximum of the second endothermic peak was used for the determination of the melting temperature of the substance.
The melting temperature of the substance was determined in duplicate obtaining a mean value of 1.7°C.
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