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Short-term toxicity to aquatic invertebrates

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Description of key information

16Alpha-Hydroxyprednisolone has an effect on Daphnia mobility (60 and 75% immobilisation) after 48 h exposure at 97.8 and 206 mg/L, the highest concentrations employed.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
109 mg/L

Additional information

The acute toxicity of 16Alpha-Hydroxyprednisolone to Daphnia magna was assessed under static exposure conditions, in a new study according to GLP and OECD No 202 guideline.Based on mean measured concentrations, the 48-hour EC50 of 16Alpha-Hydroxyprednisolone for the immobilisation of Daphnia magna was calculated to be 109 mg/L (95% confidence limits of 97.8 and 41.6 mg/L), and the ‘no-observed effect concentration’ of 16Alpha-Hydroxyprednisolone to Daphnia magna was 41.6 mg/L.