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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26 February 2018 to 29 August 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Physical Form: Brown viscous liquid to paste
- Purity: 99.9 %
Analytical method:
other: liquid chromatography mass spectrometry
Key result
Type:
log Pow
Partition coefficient:
1.81
Remarks on result:
other: Component 1
Key result
Type:
log Pow
Partition coefficient:
3.05
Remarks on result:
other: Component 2

Summary of Results

 

Test

Solubility in n-Octanol (mg/L)

Solubility in Water (mg/L)

LogPow

m/z 127 Test 1

28756

414

1.84

m/z 127 Test 2

23935

403

1.77

m/z 127 Mean

26346

409

1.81

m/z 262 Test 1

67311

52.07

3.11

m/z 262 Test 2

56507

57.93

2.99

m/z 262 Mean

61909

55.0

3.05

 

Conclusions:
The partition coefficient (LogPow) of the test substance has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262).
Executive summary:

In a study performed to the standardised guideline EU Test Method A.8 under GLP conditions, the partition coefficient (LogPow) of the test substance has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262).

Description of key information

In a study performed to the standardised guideline EU Test Method A.8 under GLP conditions, the partition coefficient (LogPow) of the test substance has been determined to be 1.81 for Component 1 (m/z 127) and 3.05 for Component 2 (m/z 262) (Intertek, 2018).

Key value for chemical safety assessment

Additional information