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EC number: 220-006-9 | CAS number: 2601-33-4
The acute oral median lethal dose (LD50) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2332 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight) (Globally Harmonised Classification System Category 5 >2000 - 5000 mg/kg bodyweight).
The study was performed to assess the acute oral toxicity of the test material following a single oral administration in the Sprague-Dawley CD strain rat. The method was designed to meet the requirements of the following:
• OECD Guidelines for the Testing of Chemicals No. 423 "Acute Oral Toxicity- Acute Toxic Class Method" (adopted 17 December2001)
• Method B1IrisAcuteToxicity (Oral)ofCommissionDirective2004/73/EC
A group of three fasted females was treated with the test material at a dose level of 2332 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight). This was followed by a further group of three fasted females at the same dose level.
The test material was administered orally as a suspension in dried arachis oil. Clinical signs and bodyweight development were monitored during the study. All animals were subjected to gross necropsy.
One animal was found dead two days after dosing and one other animal was killed in extremis four days after dosing.
Signs of systemic toxicity noted during the study were hunched posture, diuresis, diarrhoea,red/brown staining around the ano-genital region,eyes,snout and mouth, pilo-erection,lethargy, emaciation and dehydration. Surviving animals appeared normal four to nine days after dosing.
The surviving animals showed expected gains in bodyweight over the study period,except for one animal which showed a bodyweight loss during the first week but expected gain in bodyweight during the second week.
Abnormalities noted at necropsy of the animals that died or were killedin extremisduring the study and one animal killed at the end of the study were abnormally red lungs, dark or patchy pallor of the liver, dark kidneys, gaseous stomach and stomach adhered to abdominal wall. No abnormalities were noted at necropsy of remaining animals that were killed at the end of the study.
The acute oral median lethal dose (LDso) of the test material in the female Sprague-Dawley CD strain rat was estimated to be greater than 2332 mg/kg bodyweight (equivalent to 2000 mg active ingredient/kg bodyweight) (Globally Harmonised Classification System Category 5 >2000 - 5000 mg/kg bodyweight).
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