Registration Dossier
Registration Dossier
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EC number: 401-310-2 | CAS number: 93912-64-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been presented to ECHA in the framework of a NONS notification. The document is now public because presented more than 12 years ago.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Based on OECD 401 but performed to meet requirements of US and Japan
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 401-310-2
- EC Name:
- -
- Cas Number:
- 93912-64-2
- Molecular formula:
- Hill formula: C37H23N10O22S7Cl.6Na CAS formula: C37H23N10O22S7ClNa6
- IUPAC Name:
- Hexasodium 2-[8-amino-7-[[5-[[4-chloro-6-[[3-[[2-(sulfato)ethyl]sulfonyl]phenyl]amino]-1,3,5-triazin-2-yl] amino]-2 sulfonatophenyl]azo]-1-hydroxy-3,6-disulfonato-2-naphthalenyl]azo]-naphthalene-1,5-disulfonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Male: 5000 mg/kg bw; Number of animals: 10; Number of deaths: 0
Male: 2500 mg/kg bw; Number of animals: 10; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 10; Number of deaths: 0
Male: 500 mg/kg bw; Number of animals: 10; Number of deaths: 0
Male: 250 mg/kg bw; Number of animals: 10; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 10; Number of deaths: 2
Female: 2500 mg/kg bw; Number of animals: 10; Number of deaths: 0
Female: 1000 mg/kg bw; Number of animals: 10; Number of deaths: 0
Female: 500 mg/kg bw; Number of animals: 10; Number of deaths: 0
Female: 250 mg/kg bw; Number of animals: 10; Number of deaths: 0
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Clinical signs:
- Signs of toxicity related to dose levels:
No clinical signs noted at 500 or 1000 mg/kg although male animals showed a decrease of spontaneous activity over 1000 mg/kg. - Gross pathology:
- Effects on organs:
No significant dose-related effects.
Any other information on results incl. tables
sex |
dose (mg/kg) |
number of animals |
number of deaths |
M |
5000 2500 1000 500 250 |
10 10 10 10 10 |
0 0 0 0 0 |
F |
5000 2500 1000 500 250 |
10 10 10 10 10 |
2 0 0 0 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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