Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study planned
Justification for type of information:
TESTING PROPOSAL

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out: IUPAC name: N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide
CAS number: 215917-77-4

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Available GLP studies : There are no GLP studies available covering sub-chronic repeated dose toxicity information requirements.
- Available non-GLP studies : There are no non-GLP studies available covering sub-chronic repeated dose toxicity information requirements.
- Historical human data : There are no historical human data available on repeated dose toxicity for the substance.
- (Q)SAR : The online platform Chemicalize (ChemAxon) provides structure-based calculations and predictions for the dissociation constant. By using this tool, a pKa of 7.29 was predicted for N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide.
- Weight of evidence : There are no data available which are sufficient for weight of evidence approach.
- Grouping and read-across : No substances or a category of substances are known which apply for read across for this endpoint.

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)

Test material

Constituent 1
Chemical structure
Reference substance name:
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide
EC Number:
806-543-7
Cas Number:
215917-77-4
Molecular formula:
C19H17N3O3S
IUPAC Name:
N-{2-[(phenylcarbamoyl)amino]phenyl}benzenesulfonamide

Results and discussion

Applicant's summary and conclusion