Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 430-050-2 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Ames)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- A mixture of: N,N'-ethane-1,2-diylbis(decanamide); 12-hydroxy-N-[2-[1-oxydecyl)amino]ethyl]octadecanamide; N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide)
- EC Number:
- 430-050-2
- EC Name:
- A mixture of: N,N'-ethane-1,2-diylbis(decanamide); 12-hydroxy-N-[2-[1-oxydecyl)amino]ethyl]octadecanamide; N,N'-ethane-1,2-diylbis(12-hydroxyoctadecanamide)
- Molecular formula:
- C90H180N6O9
- IUPAC Name:
- 12-hydroxy-N-[2-(12-hydroxyoctadecanamido)ethyl]octadecanamide; N-(2-decanamidoethyl)-12-hydroxyoctadecanamide; N-(2-decanamidoethyl)decanamide
- Test material form:
- solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium, strains TA1535, TA1537, TA98, TA100. Escherichia coli WP2uvrA (pKM101) bacteria
- Metabolic activation system:
- Liver S9 derived from phenobarbital/B-napthoflavone-induced Sprague Dawley rats.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 100 ... 5000 μg/plateConcentration range in the main test (without metabolic activation): 100 ... 5000 μg/plate
- Vehicle / solvent:
- Solvent: Dried dimethylsulphoxide
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 5000 μg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Additional information on results:
- Observations:None.
- Remarks on result:
- other: other: preliminary test Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):negative with metabolic activationnegative without metabolic activation
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