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EC number: 812-619-0 | CAS number: 1626394-43-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 February - 22 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Visual observation
Test material
- Reference substance name:
- (2S,3S)-3-(ethoxycarbonyl)bicyclo[2.2.2]octan-2-aminium chloride
- Cas Number:
- 1626394-43-1
- Molecular formula:
- C11H19NO2.HCl
- IUPAC Name:
- (2S,3S)-3-(ethoxycarbonyl)bicyclo[2.2.2]octan-2-aminium chloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Physical state: powder
- Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- - Batch n°: M16HD2757
- Analytical purity: 95.1% (determined by GC assay)
- Expiration date: 04 July 2018
- Storage condition: at room temperature
Results and discussion
Water solubility
- Key result
- Water solubility:
- > 1 000 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 1.2 h
- Temp.:
- 19.7 °C
- pH:
- 2.4
- Details on results:
- After the stirring period, the test sample was clear and no undissolved test item was observed. Therefore, it was concluded that the water solubility of JNJ-63756992-AAC (T003680) at 20°C is > 1 x 10³ g/L.
The pH of the aqueous sample was 2.4.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test item at 20°C was determined to be > 1 x 10³ g/L.
The pH of the aqueous sample was 2.4.
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