Registration Dossier
Registration Dossier
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EC number: 919-697-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
The substance is practically non-toxic after single oral exposure (LD50 rat: > 5000 mg/kg bw) or after single dermal exposure (LD50 rat: > 2000 mg/kg bw).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The study is GLP compliant and is of high quality (Klimisch score=1)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The study is GLP compliant and is of high quality (Klimisch score=1)
Additional information
The acute oral toxicity of the substance was low with a LD50 value exceeding 5000 mg/kg bw in rats according to OECD TG 423 (Gillissen, 2010a). A single oral administration of the test substance by gavage to male and female rats at a dose of 2000 mg/kg bw was tolerated without mortalities, clinical signs, effects on body weight gain or gross pathological findings.
The acute dermal toxicity of the substance was low with a LD50 value exceeding 2000 mg/kg bw in rats according to OECD TG 402 (Gillissen, 2010b). Single semiocclusive administration of 2000 mg/kg bw for 24 hours was tolerated without mortalities, clinical signs, effects on body weight gain or gross pathological findings.
Justification for selection of acute toxicity – oral endpoint
Only one study available
Justification for selection of acute toxicity – dermal endpoint
Only one study available
Justification for classification or non-classification
Based on the study results a classification according to Regulation (EC) No.1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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