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EC number: 271-434-8 | CAS number: 68555-58-8
The acute oral toxicity of the test substance was examined in a GLP-compliant study according to OECD 401. Four concentrations of the test substance were administered orally to male and female Wistar rats. All animals were monitored for clinical signs and body weight changes during a 14-day observation period after administration. They were subjected to a necropsy at the end of the observation period. Effects of the application:
1087 mg/kg bw: no mortality
2174 mg/kg bw: 1 dead animal after 7 days
3261 mg/kg bw: 3 dead animals after 24h, 1 dead animal after 7 days
4348 mg/kg bw: 4 dead animals after 24 h (100%)
In all dosage groups animals seemed paralysed with fear and compound caused abdominal ache syndrome, pinched eyes, ataxia, disturbances of coordination and decreased readiness for reflection. These symptoms changed into sedation and coma. Furthermore, two late mortalities did occur within 72 hours. The surviving animals did not show test specific changes or dose-related weight gains. Clear decreased weight gains compared to the normal body-weights occurred. At autopsy of acute mortalities and final autopsy no treatment-related anatomical-pathological findings were made macroscopically in the thorax and cranium cavity. Alone the belly cavity appeared with hyperemiae in the gastro-intestinal tract of acute mortalities. Final autopsy of surviving animals did not show any other alterations. Based on these results, the LD50 value was determined to be 3098 mg/kg bw after 24 h and 2717 mg/kg bw after 14 days.
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