Registration Dossier

Administrative data

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 December 2017 - 07 June 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
2012
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
Version / remarks:
2002
Deviations:
no
GLP compliance:
yes
Type of method:
air comparison pycnometer (for solids)

Test material

Constituent 1
Chemical structure
Reference substance name:
(8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
EC Number:
608-630-3
Cas Number:
31528-46-8
Molecular formula:
C20H24O2
IUPAC Name:
(8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Test material form:
solid: particulate/powder
Details on test material:
Appearance: Off-white powder
Test item storage: At room temperature
Specific details on test material used for the study:
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
The test item was dried in a desiccator under vacuum using silica gel as the drying agent at 20.2 ± 0.3°C for 99 hours.
Dynamic viscosity of test material:
not applicable (substance is a solid)

Results and discussion

Densityopen allclose all
Key result
Type:
relative density
Density:
1.24 other: dimensionless
Temp.:
20 °C
Remarks on result:
other: D 20 /4
Key result
Type:
density
Density:
1.24 g/cm³
Temp.:
20 °C

Any other information on results incl. tables

Experiment 1: 1.244 g/cm^3

Experiment 2: 1.242 g/cm^3

The individual measurements were obtained with an accuracy of < 0.02 g/cm^3.

Applicant's summary and conclusion

Conclusions:
The relative density D20/4 of the substance was determined to be 1.24.
Executive summary:

The relative density of the solid substance was determined at 20°C using a gas comparison pycnometer in a GLP study according to EC A.3, OECD 109 and OPPTS 830.7300.

The relative density D20/4 was determined in duplicate obtaining a mean value of 1.24.