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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 Sep - 31 Oct 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: OECD Guideline 105
Version / remarks:
According to ECHA “Guidance on Information Requirements and Chemical Safety Assessment - Chapter R.7a: Endpoint specific guidance” (version 6.0, 2017), table “Table R.7.1-6 Methods for determination of partition coefficient n-octanol/water”, there is no current guideline to measure the solubility in octanol. A test method can be based on the principled of OECD Guideline 105.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Solubility in organic solvents / fat solubility
Medium:
n-octanol
Solubility:
< 20 mg/L
Temp.:
20 °C
Test substance stable:
not determined

Any other information on results incl. tables

Calibration

The calibration of the analytical method resulted in the following calibration curve:

R-Square: 99.8813%

Offset: -0.1313

Slope: 0.1038

Curve: 0.0006

 

 

Study results

The concentrations of the different test solutions were calculated automatically using the equation of the calibration curve. The results are summarised in the table below:

 

Test muxture

Time [h]

Average of test item [mg/L]

Total average of test item [mg/L]

1

24

< 20

< 20

2

48

< 20

3

72

< 20

 

n-Octanol solubility of the test item Sodium Hydroxymethanesulphonate is < 20 mg/L.

The n-octanol solubility was determined at 20 °C.

Applicant's summary and conclusion