Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
As neither the HPLC method (OECD 117) or shake flask method (OECD 107), nor the slow stirring shake flask method (OECD 123) are applicable to this substance, thus the determination is based on the calculation of the Log Kow using a fragment constant methodology.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
As neither the HPLC method (OECD 117) or shake flask method (OECD 107), nor the slow stirring shake flask method (OECD 123) are applicable to this substance, thus the determination is based on the calculation of the Log Kow using a fragment constant methodology.
GLP compliance:
no
Partition coefficient type:
octanol-water

Test material

1
Reference substance name:
Silybum marianum extract
Molecular formula:
Not applicable
IUPAC Name:
Silybum marianum extract
Test material form:
liquid
Details on test material:
The test matérial contains 0.5% of tocophérol for stability

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
> 6.76 - 11.67
Temp.:
25 °C
pH:
7
Remarks on result:
other: QSAR estimation

Applicant's summary and conclusion

Conclusions:
The log Kow of the individual compounds were estimated with EPISUITE, KOWWIN Program (v1.68), and log Kow values between 6.76 and 11.67 were obtained depending on the length of the fatty acid chains (between C14 and C24) and the number of double bonds.
Executive summary:

The log Kow of the individual compounds were estimated with EPISUITE, KOWWIN Program (v1.68), and log Kow values between 6.76 and 11.67 were obtained depending on the length of the fatty acid chains (between C14 and C24) and the number of double bonds.