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EC number: 949-141-8 | CAS number: -
Table 9: INDIVIDUAL AND AVERAGE VALUES FOR EVALUATION OF CORNEAL LESIONS AFTER TREATMENT
Corneal swelling (%)
Combination of the 3 Endpoints
1 x I, 1 x II, 1 x IV
No prediction can be made
Note: No morphological effects were noted, whatever the examination time.
Table 8: INDIVIDUAL AND AVERAGE VALUES FOR EVALUATION OF CORNEAL LESIONS AFTER TREATMENT
3 x IV
Category 1 : Corrosive/Severe irritant
Table 7: INDIVIDUAL AND AVERAGE VALUES FOR EVALUATION OF CORNEAL LESIONS AFTER TREATMENT
3 x I
An in vitro (ex vivo) study was conducted in order to determine the potential severe eye damaging effects of the test item according to the OECD guideline 438 under GLP conditions. Eyeballs were isolated from chickens killed for human consumption and after the appropriate preparation were exposed to either 30 μL of the test item, 30 μL of 5% Benzalkonium chloride (positive control) or 30μL of physiological saline (negative control). Three eyeballs were used in test item and positive groups, and one for the negative control group. Fluorescein retention, corneal opacity and corneal swelling were evaluated, then the results of each endpoint were assigned to ICE classes according to OECD guideline 438. Under experimental conditions, no prediction can be made for the test item in the ICE test since the combination of the 3 endpoints was 1 x IV, 1 x II, 1 x I.
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