3-[2-({[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}amino)pyridin-3-yl]prop-2-yn-1-ol

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vivo (LLNA)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)

Version / remarks:

2010

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)

Version / remarks:

2008

Test guideline 3

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 870.2600 (Skin Sensitisation)

Version / remarks:

2003

Principles of method if other than guideline:

In this modified LLNA study the index of lymph node weight and cell-count were used as relevant endpoints and the ear swelling measured (index of the ear weight) was used as an additional parameter to assess the irritant potential of the test item. The validity of this modified LLNA had been shown in an interlaboratory validation study:

Ehling G, Hecht M, Heusener A, Huesler J, Gamer AO, van Loveren H, Maurer Th, Riecke K, Ullmann L, Ulrich P, Vandebriel R and Vohr H-W, An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 1st round, Toxicology 212, 60-68, 2005A
Ehling G Hecht M, Heusener A, Huesler J, Gamer AO, van Loveren H, Maurer Th, Riecke K, Ullmann L, Ulrich P, Vandebriel R and Vohr H-W, An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 2nd round, Toxicology 212, 69-79, 2005B

GLP compliance:

yes

Type of study:

mouse local lymph node assay (LLNA)

Test material

Test material information

Constituent 1

Reference substance name:

3-[2-({[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}amino)pyridin-3-yl]prop-2-yn-1-ol

Cas Number:

2092997-91-4

Molecular formula:

not applicable

IUPAC Name:

3-[2-({[4-methanesulfonyl-2-(trifluoromethyl)phenyl]methyl}amino)pyridin-3-yl]prop-2-yn-1-ol

Results and discussion

In vivo (LLNA)

Results

Results 1

Parameter:

other: cell count index

Value:

1.19

Test group / Remarks:

test substance (0.5%)

Results 2

Parameter:

other: cell count index

Value:

1.41

Test group / Remarks:

test substance (5%)

Results 3

Parameter:

other: cell count index

Value:

1.8

Test group / Remarks:

test substance (50%)

Results 4

Parameter:

SI

Test group / Remarks:

test substance (0.5%)

Remarks on result:

not measured/tested

Results 5

Parameter:

SI

Test group / Remarks:

test substance (5%)

Remarks on result:

not measured/tested

Results 6

Parameter:

SI

Test group / Remarks:

test substance (50%)

Remarks on result:

not measured/tested