Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Batch 44034
Description: Cream to light grey powder
Expiry date: 30 November 2019
Storage conditions: Controlled room temperature (15-25 ºC, below 70 RH%).

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
< 1
Temp.:
25 °C
pH:
>= 7 - <= 9

Any other information on results incl. tables

The three calibration series and three test item series were measured. The partition coefficient Powwas determined based on a calibration curve using 6 reference substances.

The capacity factors k were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Powvalues.

The equation of the curve fitted to the calibration points is as follows:

log Pow= 2.53 × log k + 1.89 (r2= 0.937)

Applicant's summary and conclusion

Conclusions:
The estimated log Pow is < 1.0.
Executive summary:

In the course of this study the partition coefficient (log Pow) of Sodium [(6-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy]acetate was estimated using high performance liquid chromatography.

The estimated log Powis < 1.0.