Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: non-GLP guideline study, but test procedure well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Principles of method if other than guideline:
In an agitated and filtrated mixture of the test item, a concentration below 10 mg/L was measured during validation. Therefore, the preliminary study was not performed. Solubility could be limited as lying below 10 mg/L and the main study was conducted using the column elution method.
GLP compliance:
no
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-chlorophenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- Expiration date of the lot/batch: December 2012
- Storage condition of test material: Room Temperature: (20 ± 5°C); Keep away from humidity

Results and discussion

Water solubilityopen allclose all
Water solubility:
0.33 mg/L
Temp.:
22.5 °C
pH:
6
Remarks on result:
other: Flow rate of 24.4 mL/hour, standard deviation is 0.013 mg/L
Water solubility:
0.336 mg/L
Temp.:
23.2 °C
pH:
6
Remarks on result:
other: Flow rate of 12.3 mL/hour, standard deviation is 0.011 mg/L
Water solubility:
0.333 mg/L
Temp.:
22.85
pH:
6
Remarks on result:
other: Total mean value, standard deviation is 0.012 mg/L

Applicant's summary and conclusion

Conclusions:
Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of the test substance has been determined to be 0.333 mg/L (pH = 6; temperature ~ 23 °C) and therefore the substance is considered to be slightly soluble in water.