Registration Dossier

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
05 October 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached documents: QMRF and QPRF

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Principles of method if other than guideline:
(Q)SAR prediction using EPISuite/BIOWIN model

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent
Type:
Constituent

Results and discussion

% Degradation
Key result
Parameter:
probability of ready biodegradability (QSAR/QSPR)
Remarks on result:
readily biodegradable based on QSAR/QSPR prediction

Applicant's summary and conclusion

Conclusions:
Likelihoods of ready biodegradability were predicted for the six constituent substances of chamomile oil (UVCB) using EPISuite (BIOWIN model). The predictions obtained were weighted by molecular weight fraction to calculate an overall prediction for chamomile oil. Where it was known experimentally whether a constituent was or was not readily biodegradable, this information superseded the prediction for that constituent. Overall, chamomile oil was predicted to be readily biodegradable.
Executive summary:

Likelihoods of ready biodegradability were predicted for the six constituent substances of chamomile oil (UVCB) using EPISuite (BIOWIN model). The predictions obtained were weighted by molecular weight fraction to calculate an overall prediction for chamomile oil. Where it was known experimentally whether a constituent was or was not readily biodegradable, this information superseded the prediction for that constituent. Overall, chamomile oil was predicted to be readily biodegradable.