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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The study predates GLP and the description of method is not provided.

Data source

Reference
Reference Type:
publication
Title:
Studies on the Toxicity of Phthalates via Ingestion
Author:
Krauskopf L G
Year:
1973
Bibliographic source:
Environmental Health Perspectives 3:61-72.

Materials and methods

Principles of method if other than guideline:
- Principle of test: Rats given single doses of DUP of up to at least 15.8 g/kg bw.
- Short description of test conditions: No data on test method.
- Parameters analysed / observed: Animals observed for signs of toxicity.
GLP compliance:
no
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diundecyl phthalate
EC Number:
222-884-9
EC Name:
Diundecyl phthalate
Cas Number:
3648-20-2
Molecular formula:
C30H50O4
IUPAC Name:
1,2-diundecyl benzene-1,2-dicarboxylate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
up to at least 15.8 g/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 15 800 mg/kg bw
Based on:
test mat.
Mortality:
No mortality occurred during the study.
Clinical signs:
other: No significant toxic effects

Applicant's summary and conclusion

Interpretation of results:
other: Not classified (CLP Regulation EC no. 1272/2008)
Conclusions:
The acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.
Executive summary:

A single dose toxicity study was conducted with DUP in rats up to at least 15.8 g/kg bw. No mortalities were reported. Under the conditions of this study DUP was considered practically non-toxic. Thus, it can be concluded that the acute oral LD50 value of the test substance is higher than 15.8 g/kg bw in rats.