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Diss Factsheets
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EC number: 213-214-6 | CAS number: 930-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- dec 2017 - dec 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Identity: Triazolone
Appearance: Off-white powder
Storage conditions: Room temperature (15 to 25°C), dark
Batch number: 0727/16
Purity: 99%
Expiry date: 28 April 2019
Date received: 28 April 2017 - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Preliminary test
The following procedure was carried out at each of pH 4, 7 and 9:
Aliquots (0.2 mL) of a stock solution of Triazolone in purified water (40 g/L) were added to separate Wheaton vials containing buffer solution (10 mL), which had been purged with nitrogen and pre-equilibrated at test temperature (50 ± 0.5°C).
The samples, of nominal concentration 800 mg/L, were placed in a 50°C oven in the dark until sampling was required (immediately, and then after 2.4, 24 and 163 hours).
At each sampling time, two samples were removed from the bath and an aliquot (1 mL) of each was diluted to volume (20 mL) with mobile phase for analysis by high performance liquid chromatography (HPLC).
Sample pH and incubation temperature were monitored over the period of the test. - Buffers:
- Buffer solutions were prepared as follows:
pH 4: 0.2M aqueous potassium dihydrogen orthophosphate (550 mL) was mixed with
0.07M aqueous disodium hydrogen orthophosphate dodecahydrate (1250 mL) and purified water (3200 mL). The pH was adjusted to 4.0 ± 0.05 with orthophosphoric acid.
pH 7: 0.2M aqueous potassium dihydrogen orthophosphate (1250 mL) was mixed with
1M sodium hydroxide (150 mL) and purified water (3660 mL). The pH was adjusted to
7.0 ± 0.05 with 1M hydrochloric acid.
pH 9: 0.1M boric acid in 0.1M aqueous potassium chloride (2500 mL) was mixed with
1M sodium hydroxide (105 mL) and purified water (2395 mL). The pH was adjusted to
9.0 ± 0.05 with 1M hydrochloric acid or 1M sodium hydroxide, as required. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 99.05 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 99.05 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 99.05 mg/L
- Number of replicates:
- in accordance to guidelines
- Preliminary study:
- yes
- Transformation products:
- no
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- Triazolone was determined to be hydrolytically stable under acidic, neutral and basic conditions.
- Executive summary:
A study was performed to determine the rate of hydrolysis of Triazolone as a function of pH. The test was conducted in accordance with the preliminary test as described in Council Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for Testing of Chemicals (Method 111).
The preliminary study showed that at each of pH 4, 7 and 9 and 50±0.5ºC, less than 10% hydrolysis had occurred after 5 days, equivalent to a half-life of greater than 1 year under environmental conditions (25°C). No further testing was considered necessary. Triazolone was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Reference
Standard concentration (mg/L) |
Peak area |
|
|
99.05 |
2907.9 |
79.24 |
2368.4 |
59.43 |
1794.8 |
39.62 |
1222.3 |
19.81 |
616.79 |
9.905 |
310.17 |
4.952 |
155.67 |
|
Ct (mg/L) |
|||||||
pH |
t0h |
t2.4h |
t24h |
t163h |
||||
|
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
Measured |
Mean |
|
|
|
|
|
|
|
|
|
4 |
558*, 809 |
809 |
808, 809 |
808 |
808, 825 |
817 |
796, 811 |
804 |
|
|
|
|
|
|
|
|
|
7 |
798, 801 |
799 |
813, 754 |
784 |
819, 800 |
809 |
799, 817 |
808 |
|
|
|
|
|
|
|
|
|
9 |
799, 802 |
801 |
798, 799 |
799 |
795, 801 |
798 |
805, 797 |
801 |
|
|
|
|
|
|
|
|
|
Description of key information
Triazolone was determined to be hydrolytically stable under acidic, neutral and basic conditions.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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