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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Jul 2017 - 07 Sep 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Remarks:
See cross reference for analytical method
Key result
Water solubility:
9.33 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 7.1 - <= 7.2
Details on results:

-Concentration analysed after 24, 48 and 72 hours of stirring: 9.36 g/L, 9.23 g/L and 9.40 g/L, resp.
-Maximum difference meets the criterion of ≤ 15% (i.e. 1.8%)
-The mean of the three concentrations was reported as the water solubility of the substance.


Conclusions:
The water solubility of the substance at 20°C was determined to be 9.33 g/L.
Executive summary:

The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by HPLC. The pH of the aqueous samples was between 7.1 and 7.2. From the measurements obtained after 24, 48 and 72 hours of stirring, the mean water solubility at 20°C was determined to be 9.33 g/L.

Description of key information

The water solubility at 20°C was determined to be 9.33 g/L.

The pH of the aqueous samples was between 7.1 and 7.2.

Key value for chemical safety assessment

Water solubility:
9.33 g/L
at the temperature of:
20 °C

Additional information

Determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by HPLC.