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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2c: Comparable to guideline study with acceptable restrictions
equivalent or similar to guideline
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
Two independant trials were conducted. Excess of diphenylnitrosamine were added into water in a sealed stainless steel centrifuge tubes and kept at 25°C for one week with intermittent shaking. The mixture was then centrifuged at 10 000 rpm for 60 min following which aliquots of the solution were removed for quantification assay. Quantification was done either by GC, HPLC or UV-spectrometry, but it is not clearly explained which of these methods was used.
GLP compliance:
Type of method:
flask method
Water solubility:
177 other: µM
25 °C
Remarks on result:
other: 177 µM is 35 mg/L
Details on results:
Measured solubility was 177 µM.

Remark: since M=177 g/mol, it can be converted to 35 mg/L
Solubility was 177 µM (i.e. 35 mg/L)
Executive summary:

Solubility was tested at 25°C. Diphenylnitrosamine was added in excess into water in stainless steel tubes. These were intermittently shaken for one week. Quantification was done with GC, UV spectrometry or HPLC (not precisely indicated in the paper). Solubility was 177 µM (i.e. 35 mg/L).

Description of key information

One detailed experimental study indicates a solubility of 35 mg/L (Banerjee, 1980) while another dateline found within a literature review is 50 mg/L (Smith-Simon, 1993). These solubilities are close. Therefore, the solubility indicated in the detailed study is considered fo registration.

Key value for chemical safety assessment

Water solubility:
35 mg/L
at the temperature of:
25 °C

Additional information