Nitrosodiphenylamine

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: 2c: Comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Principles of method if other than guideline:

Two independant trials were conducted. Excess of diphenylnitrosamine were added into water in a sealed stainless steel centrifuge tubes and kept at 25°C for one week with intermittent shaking. The mixture was then centrifuged at 10 000 rpm for 60 min following which aliquots of the solution were removed for quantification assay. Quantification was done either by GC, HPLC or UV-spectrometry, but it is not clearly explained which of these methods was used.

GLP compliance:

no

Type of method:

flask method

Water solubility:

177 other: µM

Temp.:

25 °C

Remarks on result:

other: 177 µM is 35 mg/L

Details on results:

Measured solubility was 177 µM.

Remark: since M=177 g/mol, it can be converted to 35 mg/L

Conclusions:

Solubility was 177 µM (i.e. 35 mg/L)

Executive summary:

Solubility was tested at 25°C. Diphenylnitrosamine was added in excess into water in stainless steel tubes. These were intermittently shaken for one week. Quantification was done with GC, UV spectrometry or HPLC (not precisely indicated in the paper). Solubility was 177 µM (i.e. 35 mg/L).

Description of key information

One detailed experimental study indicates a solubility of 35 mg/L (Banerjee, 1980) while another dateline found within a literature review is 50 mg/L (Smith-Simon, 1993). These solubilities are close. Therefore, the solubility indicated in the detailed study is considered fo registration.

Key value for chemical safety assessment

Water solubility:

35 mg/L

at the temperature of:

25 °C