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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: 2c: Comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Principles of method if other than guideline:
Octanol was purified by extraction with water and with aqueous NaOH, followed by distillation. A mixture of octanol and water was shaken for 30 min and separated by centrifugation (10 000 rpm, 30 min), and diphenylnitrosamine was dissolved in the water-saturated octanol. The octanol-saturated water was then added to the stainless steel tube which was sealed, and the mixture was equiibriated during several 4-5 min shaking periods spaced 10 min apart. The tubes were centrifuged for 30 min at 10 000 rpm and both the octanol and water layers were sampled and analysed. The contentration in the water was far below the solubility limit. The octanol fraction was diluted with methanol before analysis. Radiolabelled C14 molecules were used for liquid scintillation counting.
GLP compliance:
no
Type of method:
other: Liquid Scintillation Counting
Partition coefficient type:
octanol-water
Analytical method:
other: Liquid scintillation counting
Type:
log Pow
Partition coefficient:
3.13
Temp.:
25 °C
Remarks on result:
other: pH was not indicated
Conclusions:
Log Pow was 3.13
Executive summary:

Log Pow was obtained by a method similar to the flask method described in the OECD 107 guidelines. Diphenylnitrosamine was dissolved in water-saturated octanol. This mixture was added in stainless steel tubes with water and intermittently shaken. Quantification within both octanol and water were performed by liquid scintillation counting. Log Pow was 3.13

Description of key information

One detailed experimental study indicates a log Kow of 3.13 (Banerjee et al., 1980).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.13
at the temperature of:
25 °C

Additional information