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EC number: 807-935-0 | CAS number: 1244733-77-4
In the absence of metabolic activation, there was no significant increase in mutation frequency in either the first or second experiment up to toxic doses. In the presence of S9, statistically significant increases in mutation frequency were observed at the highest doses in both the first (137.5, 150 and 200 µg/ml) and second (150, 175 and 200 µg/ml) experiment. The relative total growth (RTG) at these doses were 52, 58 and 41% in the first experiment and 28, 18 and 10% in the second experiment, respectively. Large and small colonies were scored for the doses at which statistically significant increases in mutation frequency were observed. Increases in both small and large colony mutant frequencies were noted as well as a clear increase in the proportion of small colony mutants, indicating potential clastogenic activity.
When tested up to toxic doses, tris(2-chloro-1methylethyl) phosphate induced mutation at the tk locus of L5178Y mouse lymphoma cells in two independent experiments in the presence of S9, but did not induce mutation in two independent experiemnts in the absence of S9. It is concluded that under the conditons employed in the study, Tris(2-chloro-1-methylethyl) phosphate was mutagenic in this test system in the presence of S9, but not in the absence of S9.
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