Reaction products of phosphoryl trichloride and 2-methyloxirane

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No OECD Guideline or GLP study defined.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Materials and methods

Type of study / information:

in vivo

Endpoint addressed:

skin irritation / corrosion

Principles of method if other than guideline:

Method: other: 8 volunteers, 50 µl on a cotton pad, fixed on the arm by a tape, post exposure observation time: 7 days

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate

EC Number:

807-935-0

Cas Number:

1244733-77-4

Molecular formula:

C9H18Cl3O4P

IUPAC Name:

1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate

Method

Details on study design:

Method: other: 8 volunteers, 50 µl on a cotton pad, fixed on the arm by a tape, post exposure observation time: 7 days

Exposure assessment:

not specified

Results and discussion

Results:

TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating.

Any other information on results incl. tables

During the 8 days observation time the treated skin of the volunteers remained unmodified.

Applicant's summary and conclusion

Executive summary:

TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating.