Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Currently viewing:

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No OECD Guideline or GLP study defined.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Type of study / information:
in vivo
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
Method: other: 8 volunteers, 50 µl on a cotton pad, fixed on the arm by a tape, post exposure observation time: 7 days
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate
EC Number:
807-935-0
Cas Number:
1244733-77-4
Molecular formula:
C9H18Cl3O4P
IUPAC Name:
1-chloropropan-2-yl bis(2-chloropropyl) phosphate; bis(1-chloropropan-2-yl) 2-chloropropyl phosphate; tris(1-chloropropan-2-yl) phosphate; tris(2-chloropropyl) phosphate

Method

Details on study design:
Method: other: 8 volunteers, 50 µl on a cotton pad, fixed on the arm by a tape, post exposure observation time: 7 days
Exposure assessment:
not specified

Results and discussion

Results:
TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating.

Any other information on results incl. tables

During the 8 days observation time the treated skin of the volunteers remained unmodified.

Applicant's summary and conclusion

Executive summary:

TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating.