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EC number: 609-567-4 | CAS number: 38661-72-2
An acute inhalation toxicity was performed equivalent to OECD 403 with 1,3H6XDI. Five male and female rats were exposed to aerosols for 4 hours (whole body exposure) and followed for 14 days. Mortality was 0, 2, 1, 0, 9 and 10 rats at 0, 72.7, 114.7, 147.1, 239.1 and 531.6 mg/m3. The time of death correlated with exposure concentration. During exposure, rats showed salivation, lacrimation, hunched or prone posture, peripheral vasodilation and laboured breathing (gasping at two highest doses). The rapidity of onset of these reactions was related to the exposure level. During observation period, laboured breathing and rales were observed in all exposed animals. Brown staining (or dark red discharge) around snouts and peripheral vasodilation was observed in all rats 3 days post exposure. Persistence of the observations was dependent on exposure concentration. Dose-dependent decrease in body weight gain was noted during first 3 to 5 days after exposure. Subsequent body weight gain was comparable to that of the control rats for rats dosed at 72.7 and 114.7 mg/m3, but for rats dosed higher body weight gain remained lower, or further decreased (at 239.1 mg/m3). Gross macroscopy revealed substance related effects in the lungs (oedema and hepatisation, dose-dependent severity). As the LD50 of 1,3-H6XDI was found to be > 147.1 mg/m3 and < 239 mg/m3, which correlates to > 0.147 mg/L and < 0.239 mg/L, 1,3H6XDI is classified as category 2 for inhalation toxicity according to Regulation EC 1272/2008.
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