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Diss Factsheets
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EC number: 605-924-3 | CAS number: 181314-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
- Type of study / information:
- The objective of the study was to evaluate if the potential of the test material to cause cutaneous irrition after a single 24 h patch application, on the skin of healthy volunteers.
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A single application of each of the test materials will be made to designated skin sites (arms) for approximately 24 hours.
Sites will be evaluated approximately 15 minutes and 24 hours after patch removal.
Reactions will be evaluated according to a numerical scale based upon the degree of irritation. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Waxes and Waxy substances, jojoba, iso-Pr esters
- EC Number:
- 605-924-3
- Cas Number:
- 181314-46-5
- Molecular formula:
- No molecular formula available (UVCB)
- IUPAC Name:
- Waxes and Waxy substances, jojoba, iso-Pr esters
- Details on test material:
- Substance %
Isopropyl Jojobate 30 – 40
Jojoba Alcohols 30 – 40
Jojoba Esters 30 – 40
Constituent 1
Method
- Ethical approval:
- confirmed and informed consent free of coercion received
- Details on study design:
- * 15 healthy male/female subjects of 18 years of age or older
* Positive control: sodium lauryl sulfate 0.3% in distilled water (w/v)
* Negative control: deionized water - Exposure assessment:
- estimated
- Details on exposure:
- * 0.2 mL applied by pipette or syringe
* occluded using a non woven cotton pad covered by and held securely on all sides with an occlusive hypoallergenic tape
Results and discussion
- Results:
- At 15 minutes after path removal, 1 out of 15 subjects presented with a slight, confluent, patchy erythema and another subject presented glazing skin.
At 24 hours after patch removal, no irritation signs were observed in any of the 15 subjects.
Applicant's summary and conclusion
- Conclusions:
- Floraesters IPJ is not irritatant to human skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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