Registration Dossier
Registration Dossier
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EC number: 805-657-4 | CAS number: 7214-08-6
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4 450 000 µg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 30
- AF for dose response relationship:
- 1
- Justification:
- standard assessment factor
- AF for differences in duration of exposure:
- 6
- Justification:
- standard assessment factor
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard assessment factor
- AF for other interspecies differences:
- 1
- Justification:
- standard assessment factor
- AF for intraspecies differences:
- 5
- Justification:
- standard assessment factor
- AF for the quality of the whole database:
- 1
- Justification:
- standard assessment factor
- AF for remaining uncertainties:
- 1
- Justification:
- not present
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 225 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 5
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.268 mg/m³
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for differences in duration of exposure:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 5
- Justification:
- standard default
- AF for intraspecies differences:
- 1
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.9 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 5
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 5
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 100 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 20
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 5
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 400 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 5
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for differences in duration of exposure:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.112 mg/m³
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 40
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for differences in duration of exposure:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.45 mg/m³
DNEL related information
- Overall assessment factor (AF):
- 10
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Dermal
DNEL related information
- Overall assessment factor (AF):
- 40
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 200 mg/cm²
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 37.5 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- Overall assessment factor (AF):
- 40
- AF for dose response relationship:
- 1
- Justification:
- standard default
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- standard default
- AF for other interspecies differences:
- 1
- Justification:
- standard default
- AF for intraspecies differences:
- 10
- Justification:
- standard default
- AF for the quality of the whole database:
- 1
- Justification:
- standard default
- AF for remaining uncertainties:
- 1
- Justification:
- standard default
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
