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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.1; OECD 401
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: rat, Wistar Hsd Cpb:WU (SPF)

Administration / exposure

Vehicle:
other: Aceton/Erdnussöl (DAB10) 4/6 (v/v)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Bei 2000 mg/kg KG und 5000 mg/kg KW verminderte Motilität, Blässe bzw. Hautrötung, spastischer Gang, erschwerte Atmung, Atemgeräusche und rote Krustenbildung an der Schnauze. Die Symptome begannen 5 - 20 Min
Gross pathology:
Effects on organs:
Die pathologische Untersuchung am Ende der Studie zeigt
dunkelrote Herde in der Lunge.

"ENGLISH"

The pathological examination after the study showed dark-red
focuses in the lung.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU