Registration Dossier
Registration Dossier
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EC number: 212-611-1 | CAS number: 831-82-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- INITIAL SUBMISSION: ACUTE ORAL AND DERMAL TOXICITY OF M-PHENOXYPHENOL IN RATS, MICE, AND GUINEA PIGS WITH COVER LETTER DATED 090892
- Author:
- U.S. Environmental Protection Agency
- Year:
- 1 992
- Bibliographic source:
- EPA-OTS0570999
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Intraperintoneally route
No other data specified - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-phenoxyphenol
- EC Number:
- 212-611-1
- EC Name:
- 4-phenoxyphenol
- Cas Number:
- 831-82-3
- Molecular formula:
- C12H10O2
- IUPAC Name:
- 4-phenoxyphenol
Constituent 1
- Specific details on test material used for the study:
- No specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- No specified
- Doses:
- 200 - 3 200 mg/kg
- No. of animals per sex per dose:
- Total : 10 rats
- Control animals:
- no
- Details on study design:
- No specified
- Statistics:
- No specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 400 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Time of deah : 0.5 hours - 6 days
- Clinical signs:
- Moderate to very weak, severe ataxia, prostration, vasodilatation, tremor, jerking, temporary hind quarter paralysis.
- Body weight:
- Yes
- Gross pathology:
- No specified
- Other findings:
- No specified
Applicant's summary and conclusion
- Conclusions:
- The approximative LD50 for rat, intraperintoneally, is 200 - 400 mg/kgbw.
- Executive summary:
The approximative LD50 for rat, intraperintoneally, is 200 - 400 mg/kgbw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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