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EC number: 946-365-8 | CAS number: -
Chromosome Aberrations in Sprague-Dawley Rats
Number of Spreads
Number of Aberrations
% Abrr. Per Metaphase
% Metaphases > 1 Abrr.
% Metaphases > 2 Abrr.
This data is being read across from the source study that tested Hydrocarbons, C9, aromatics based on analogue read across.
A rat bone marrow cytogenicity study was performed to determine the clastogenicity of high flash aromatic naphtha. 15 male and 15 female rats were exposed via inhalation to 150, 500, or 1500 ppm of high flash aromatic naphtha for 6 hrs/day for 5 days. Rats were sacrificed at 6, 24, or 48 hrs after end of exposure, and the bone marrow then examined for chromosome and chromatid aberrations.
There was no increase in the number of aberrations as compared to negative controls in any of the exposure groups. A significant increase in the number of aberrations was seen in the positive control group, therefore the test is valid.
In conclusion, the test substance is not clastogenic.
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