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EC number: 231-326-3 | CAS number: 7492-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: similar to OECD TG 401: LD50 >5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study period not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace animals
- Age at study initiation: Approx. 9 weeks
- Weight at study initiation: 169-194 g
- Fasting period before study: 16-20 hours
- Housing: Five per cage in suspended wire cages (20" x 10" x 7")
- Diet: Fresh Purina rat chow, ad libitum
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21 - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No details
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 3-4 hours after dosing and once daily for 14 days. Mortality and toxicity were recorded.
- Necropsy of survivors performed: yes, all animals were examined for gross pathology - Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- other: All animals were normal 3-4 hours post dose thru Day 5. One instance of alopecia was noted on Day 6. All animals were normal on Days 7 thru 12. One instance of diarrhea was noted on Days 13 and 14.
- Gross pathology:
- All animals, sacrificed on Day 14, were normal.
- Interpretation of results:
- other: not acute harmful
- Remarks:
- according to EU CLP Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- The acute oral toxicity test showed an LD50 of >5000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study performed similar to OECD 401 (pre-OECD) following GLP, 10 male Wistar rats were administered the test substance orally at a dose level of 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Necropsy was performed after 14 days. No mortality was observed during the study and clinical signs were limited to alopecia on day 6 in one animal and diarrhea in one animal on day 13 and 14. All animals were normal at necropsy. The acute oral LD50 for the test substance in rats was determined to be >5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The acute oral toxicity result is of sufficient quality and adequate for this dossier.
Additional information
Acute oral toxicity:
In an acute oral toxicity study performed similar to OECD 401 (pre-OECD) following GLP, 10 rats were administered the test substance orally at a dose level of 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Necropsy was performed after 14 days. No mortality was observed during the study and clinical signs were limited to alopecia on day 6 in one animal and diarrhea in one animal on day 13 and 14. All animals were normal at necropsy. The acute oral LD50 for the test substance in rats was determined to be >5000 mg/kg bw.
Acute dermal toxicity:
In the acute oral toxicity study of Moreno, 1980 also a dermal toxicity study was included, which was performed similar to OECD 402. The acute dermal toxicity study was conducted with 10 New Zealand White rabbits receiving a dermal application of 5000 mg/kg bw of the test material. The dermal LD50 exceeded 5000 mg/kg bw.
Justification for classification or non-classification
The substance does not have to be classified for acute oral toxicity in accordance with EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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