Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
Deviations:
no

Test material

Constituent 1
Radiolabelling:
yes

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
60 d
Total depuration duration:
56 d

Test conditions

Reference substance (positive control):
no

Results and discussion

Lipid contentopen allclose all
Lipid content:
6.5 %
Time point:
start of exposure
Remarks on result:
other:
Lipid content:
9.1 %
Time point:
end of exposure
Remarks on result:
other:
Lipid content:
7.9 %
Time point:
other:
Lipid content:
6.7 %
Time point:
other:
Bioaccumulation factor
Key result
Type:
BCF
Value:
1 424 dimensionless
Basis:
whole body w.w.
Calculation basis:
kinetic
Depurationopen allclose all
Key result
Elimination:
yes
Parameter:
DT50
Depuration time (DT):
19 d
Remarks on result:
other:
Key result
Elimination:
yes
Parameter:
DT50
Depuration time (DT):
18 d
Remarks on result:
other:
Rate constantsopen allclose all
Key result
Rate constant:
overall uptake rate constant (L kg-1 d-1)
Value:
165.93
Key result
Rate constant:
overall uptake rate constant (L kg-1 d-1)
Value:
160.63
Key result
Rate constant:
overall depuration rate constant (d-1)
Value:
0.037
Key result
Rate constant:
overall depuration rate constant (d-1)
Value:
0.038

Applicant's summary and conclusion

Validity criteria fulfilled:
yes