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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-11-10 to 2018-03-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: Modified flask method.
Specific details on test material used for the study:
- Batch No.of test material: PFW110370
- Purity: 99.1%
- Expiration date of the lot/batch: 31 December 2018
- Storage conditions: Room temperature, in the dark
Key result
Temp.:
20 °C
pH:
>= 11.9 - <= 13.9
Remarks on result:
completely miscible

The sample concentrations, observations and solution pH are shown in the following table:

Sample

Concentration (% w/w)

Observations

Solution pH

1

5.17

Clear colorless liquid, no excess test item.

11.9

2

23.0

Clear colorless liquid, no excess test item.

12.4

3

50.0

Clear colorless liquid, increased viscosity, no excess test item.

12.7

4

74.3

Clear colorless liquid, increased viscosity, no excess test item.

13.9

5

95.0

Clear colorless liquid, increased viscosity, no excess test item.

13.9
Conclusions:
The test item has been determined to be miscible with water in all proportions (sample concentrations ranging from 5 to 95% w/w) at 20.0 ± 0.5 °C.

Description of key information

The determination of the water solubility of the test item was carried out by visual assessment, using a modified flask method.

Therefore, a range of sample concentrations ranging from 5 to 95 % w/w were prepared for visual assessment. The test item has been determined to be miscible with water in all proportions at 20.0 ± 0.5 °C (K1, Envigo, 2018).

Key value for chemical safety assessment

Additional information

The water solubility is considered to be >100 g/L at 20°C (completely miscible)