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Description of key information

No experimental toxicokinetic study is available on  Tricyclodecanemonomethylol acrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data, QSAR models and the physicochemical properties, the absorption of Tricyclodecanemonomethylol acrylate is expected to be low by oral, dermal route and inhalation.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
10
Absorption rate - inhalation (%):
100

Additional information

No experimental toxicokinetic study is available on Tricyclodecanemonomethylol acrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physical-chemical properties, including:

-Mean molecular weight: 220 g/mol

-Water solubility: 6.48 mg/L (low solubility)

-Partition coefficient Log Kow: 5,09

-Vapour pressure: 0,0052 Pa

 

ABSORPTION

The high value of log Kow (>5) and the low solubility of Tricyclodecanemonomethylol acrylate are not favorable for an oral absorption. Indeed, no clinical effects awere observed after one single administration (2000 mg/kg) of Tricyclodecanemonomethylol acrylate by gavage (oral route) in rats.

A low oral absorption is expected for Tricyclodecanemonomethylol acrylate ; however the worst case value (100%) is used for the risk assessment.

 

With a low solubility of 6.48 mg/L, dermal absorption is anticipated to be low. With a Log Kow of 5.09, the rate of penetration may be limited by the rate of transfer between the stratum corneum and the epidermis, but uptake into the stratum corneum will be high.

However, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption.

According to the IH skin perm (QSAR), the dermal absorption of Tricyclodecanemonomethylol acrylate is 0 %.

Tricyclodecanemonomethylol acrylate showed allergic reaction in the LLNA: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose. For the risk assessment, 10% of dermal absorption is taken into account.

 

Based on the low value of the vapour pressure (<1 Pa), Tricyclodecanemonomethylol acrylate is not considered as a volatile substance.

A low absorption by inhalation is expected for Tricyclodecanemonomethylol acrylate ; however the worst case value (100%) is used for the risk assessment.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of Tricyclodecanemonomethylol acrylate.

 

ELIMINATION

Due to the low water solubility and the high log kow, the excretion of Tricyclodecanemonomethylol acrylate in the urines is not expected. An excretion via bile and faeces is possible.