Registration Dossier
Registration Dossier
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EC number: 811-684-2 | CAS number: 1255735-07-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted in 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl fluoride
- EC Number:
- 811-684-2
- Cas Number:
- 1255735-07-9
- Molecular formula:
- C6 H4 F4 N2 O
- IUPAC Name:
- 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl fluoride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD/Crl:CD(SD)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.8% aqueous hydroxypropylmethylcellulose
- Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 females (2000 mg/kg bw dose group); 6 females (300 mg/kg bw dose group)
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 2000 mg/kg bw: 3/3 animals died within 6 h; 300 mg/kg bw: 0/6 animal died
- Key result
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: acute oral toxicity observed
- Conclusions:
- A dose of 2000 mg/kg bw of the test material caused slightly to severely reduced motility, slight to severe ataxia, slightly reduced muscle tone, slight dyspnoea and abdominal position in 3/3 animals. All animals died within 6 h after administration. A dose of 300 mg/kg bw of the test material caused slightly reduced motility, slight ataxia, slightly reduced muscle tone and slight dyspnoea, abdominal position and pilo-erectionon in all animals on test day 1. No mortality was observed. All surviving animals gained the expected body weight. Necropsy and histopathological examination revealed no test material-related findings. The LD50 value was ranked between 300 and 2000 mg/kg bw. Based on these results and according to EU classification criteria, the test material has to be classified.
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