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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
other: SCCS/1511/13
Adequacy of study:
key study
Study period:
na
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Title:
Scientific Committee on Consumer Safety Opinion on Lawsonia Inermis (Henna) Colipa no C169
Author:
SCCS
Year:
2013
Bibliographic source:
ISBN 978-92-79-30118-6
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
1981
Deviations:
not specified
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Lawsonia inermis, ext.
EC Number:
284-854-1
EC Name:
Lawsonia inermis, ext.
Cas Number:
84988-66-9
Molecular formula:
na
IUPAC Name:
Lawsonia inermis, ext.
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
Not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Based on:
not specified
Mortality:
Not specified
Clinical signs:
Not specified
Body weight:
Not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The calculated oral median lethal dose was > 2000 mg/kg bw.