Registration Dossier
Registration Dossier
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EC number: 268-407-8 | CAS number: 68083-58-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Negative results were produced in three key in vitro studies; a regulatory Ames test (OECD 471) conducted with 1,3-Dimethyl-3-phenylbutyl acetate; a mouse lymphoma assay (OECD 476) and a chromosome aberration test in human lymphocytes (OECD 473) both conducted with the read-across substance, 4-Methyl-4-phenylpentan-2-ol.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Additional information from genetic toxicity in vitro:
Justification for selection of genetic toxicity endpoint
One key genetic toxicity study was conducted with the test
substance, 1,3-Dimethyl-3-phenylbutyl acetate, a reverse mutation study
in bacterial cells. Two further key in vitro genetic toxicity studies
have been conducted with the read-across substance,
4-methyl-4-phenylpentan-2-ol, an in vitro mutagenicity studies in
mammalian cells and a cytogenicity study in human lymphocytes. All key
and supporting studies had a negative outcome.
Justification for classification or non-classification
Negative results were produced in an in vitro reverse mutation test in bacterial cells with the test substance 1,3-Dimethyl-3-phenylbutyl actetate as well as in an in vitro cytogenicity study in mammalian cells and in a gene mutation study in mammalian cells for read-across substance 4-methyl-4-phenylpentan-2 -ol.
Therefore, no classification is required for this endpoint for 1,3-dimethyl-3-phenylbutyl acetate.
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