Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 268-407-8 | CAS number: 68083-58-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Negative results were produced in three key in vitro studies; a regulatory Ames test (OECD 471) conducted with 1,3-Dimethyl-3-phenylbutyl acetate; a mouse lymphoma assay (OECD 476) and a chromosome aberration test in human lymphocytes (OECD 473) both conducted with the read-across substance, 4-Methyl-4-phenylpentan-2-ol.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Additional information from genetic toxicity in vitro:
Justification for selection of genetic toxicity endpoint
One key genetic toxicity study was conducted with the test
substance, 1,3-Dimethyl-3-phenylbutyl acetate, a reverse mutation study
in bacterial cells. Two further key in vitro genetic toxicity studies
have been conducted with the read-across substance,
4-methyl-4-phenylpentan-2-ol, an in vitro mutagenicity studies in
mammalian cells and a cytogenicity study in human lymphocytes. All key
and supporting studies had a negative outcome.
Justification for classification or non-classification
Negative results were produced in an in vitro reverse mutation test in bacterial cells with the test substance 1,3-Dimethyl-3-phenylbutyl actetate as well as in an in vitro cytogenicity study in mammalian cells and in a gene mutation study in mammalian cells for read-across substance 4-methyl-4-phenylpentan-2 -ol.
Therefore, no classification is required for this endpoint for 1,3-dimethyl-3-phenylbutyl acetate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
