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Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Negative results were produced in three key in vitro studies; a regulatory Ames test (OECD 471) conducted with 1,3-Dimethyl-3-phenylbutyl acetate; a mouse lymphoma assay (OECD 476) and a chromosome aberration test in human lymphocytes (OECD 473) both conducted with the read-across substance, 4-Methyl-4-phenylpentan-2-ol.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Additional information from genetic toxicity in vitro:

Justification for selection of genetic toxicity endpoint
One key genetic toxicity study was conducted with the test substance, 1,3-Dimethyl-3-phenylbutyl acetate, a reverse mutation study in bacterial cells. Two further key in vitro genetic toxicity studies have been conducted with the read-across substance, 4-methyl-4-phenylpentan-2-ol, an in vitro mutagenicity studies in mammalian cells and a cytogenicity study in human lymphocytes. All key and supporting studies had a negative outcome.

Justification for classification or non-classification

Negative results were produced in an in vitro reverse mutation test in bacterial cells with the test substance 1,3-Dimethyl-3-phenylbutyl actetate as well as in an in vitro cytogenicity study in mammalian cells and in a gene mutation study in mammalian cells for read-across substance 4-methyl-4-phenylpentan-2 -ol.

Therefore, no classification is required for this endpoint for 1,3-dimethyl-3-phenylbutyl acetate.