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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Remarks:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
only abstract available

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Type of study / information:
Human Patch Test
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Human patch test with 5% 1,3-dimethyl-3-phenylbutyl acetate in vaseline: 24-hour occluded patch test in 50 subjects.

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dimethyl-3-phenylbutyl acetate
EC Number:
268-407-8
EC Name:
1,3-dimethyl-3-phenylbutyl acetate
Cas Number:
68083-58-9
Molecular formula:
C14H20O2
IUPAC Name:
1,3-dimethyl-3-phenylbutyl acetate
Test material form:
liquid

Method

Details on study design:
The test concentration of the substance was a 5% suspension in white petrolatum. The test area on the body was the shoulderblade. The test was performed by the patch skin test. As testing patch Leukosilk was used. The time of exposition was 24 hours. The reaction to the test was examined immediately after removal of the testing patch and 24 hours later. The Interpretation of the test reaction was based on the criteria of the International Contact Dermatitis Research Group.

Results and discussion

Results:
The preparation of the test item was tolerated by all 50 persons (22 male, 28 female) without pathological findings.

Applicant's summary and conclusion

Conclusions:
Results: not skin irritating at 5% (0/50)
Executive summary:

Human patch test with 5% test item in vaseline, 24 -hour occluded patch test in 50 subjects, resulted in no skin reactions.