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EC number: 268-407-8 | CAS number: 68083-58-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Specific investigations: other studies
Administrative data
- Endpoint:
- phototoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Test material at 5% in vaseline was applied to the skin of 10 test animals and 5 animals received the vehicle alone as a control. The treatment consisted of 0.5 g test material or vehicle plus suberythema UV irradiation. Skin reactions were observed after 2, 24 and 48 hours.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- other: Phototoxicity
Test material
- Reference substance name:
- 1,3-dimethyl-3-phenylbutyl acetate
- EC Number:
- 268-407-8
- EC Name:
- 1,3-dimethyl-3-phenylbutyl acetate
- Cas Number:
- 68083-58-9
- Molecular formula:
- C14H20O2
- IUPAC Name:
- 4-methyl-4-phenylpentan-2-yl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Lippische Versuchstierzucht Hagemann GmbH & Co. KG
- Weight at study initiation: mean: 200 g
- Housing: two animals in one tage (Macrolon Plastic cages III 14 cm high, 25 cm width, 42 cm length)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 °C +/- 2 °C
- Humidity (%): 50 - 85 %
- Photoperiod (hrs dark / hrs light):12 hours daily, from 7.00 a.m. to 7.00 p.m.
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- petrolatum
- Duration of treatment / exposure:
- 2 weeks
- Frequency of treatment:
- daily
- No. of animals per sex per dose:
- control: 5 animals
treatment group: 10 animals in total - Control animals:
- yes
- Details on study design:
- amount applied: 0.5g
Examinations
- Examinations:
- 2, 24 and 48 hours after application
Results and discussion
- Details on results:
- No skin reactions after 2, 24 or 48 hours.
Applicant's summary and conclusion
- Conclusions:
- Not phototoxic in guinea pigs
- Executive summary:
The test material, 1,3-dimethyl-3-phenylbutyl acetate at 5% in vaseline was applied to the skin of 10 test animals and 5 additional animals received the vehicle as control. The treatment consisted of a dose of 0.5 g test material (or vehicle) along with suberythemal UV irradiation. Skin was observed for reactions 2, 24 and 48 hours after application.
No skin reactions were observed in any of the 10 treated animals.
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